Early and mature endothelial progenitors and VEGFR2+-cells in multiple myeloma: association with disease characteristics and variation in different cell compartments

Leuk Res. 2011 Sep;35(9):1265-8. doi: 10.1016/j.leukres.2011.05.021.

Abstract

We analyzed (1) early endothelial progenitors (EPCs; CD34(+)/AC133(+)/VEGFR2(+)), mature EPCs (CD34(+)/VEGFR2(+)) and VEGFR2(+)-cells in bone marrow (BM)-specimens of multiple myeloma (MM)- vs. monoclonal gammopathy (MGUS)-patients and healthy controls; (2) differences of BM-, peripheral blood (PB)- and leukapheresis (LP)-samples; and (3) the association of EPCs and VEGFR2(+)-cells with MM-parameters. MM patients demonstrated highest early and mature EPCs and VEGFR2(+)-cells in the BM, particularly with advanced and active disease. Endothelial cells differed in BM-, PB- and LP-specimens, albeit seemed less associated with unfavorable prognostic MM-parameters. Our data suggest that especially VEGFR2(+)-cells and mature EPCs in MM are of value to explore further.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Case-Control Studies
  • Cell Compartmentation* / physiology
  • Disease Progression
  • Endothelial Cells / metabolism
  • Endothelial Cells / pathology
  • Endothelial Cells / physiology*
  • Female
  • Humans
  • Male
  • Middle Aged
  • Multiple Myeloma / metabolism
  • Multiple Myeloma / pathology*
  • Stem Cells / metabolism
  • Stem Cells / pathology
  • Stem Cells / physiology*
  • Vascular Endothelial Growth Factor Receptor-2 / metabolism*

Substances

  • Vascular Endothelial Growth Factor Receptor-2