Abstract
The antifungal spirocyclic guanidine alkaloid, ptilomycalin A, from marine sponge Monanchora arbuscula, inhibits melanogenesis of Cryptococcus neoformans in vitro through inhibition of biosynthesis of laccase in the melanin biosynthetic pathway with an IC(50) of 7.3 μM.
Copyright © 2011 Elsevier Ltd. All rights reserved.
Publication types
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Research Support, N.I.H., Extramural
MeSH terms
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Animals
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Antifungal Agents / pharmacology
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Cryptococcosis / microbiology
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Cryptococcus neoformans / drug effects*
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Cryptococcus neoformans / enzymology
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Cryptococcus neoformans / metabolism*
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Enzyme Inhibitors / pharmacology
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Guanidines / pharmacology*
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Laccase / antagonists & inhibitors*
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Laccase / metabolism
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Melanins / biosynthesis*
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Porifera / chemistry
Substances
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Antifungal Agents
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Enzyme Inhibitors
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Guanidines
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Melanins
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ptilomycalin A
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Laccase