Serum macrophage colony-stimulating factor (M-CSF) in patients with Hodgkin lymphoma

Med Oncol. 2012 Sep;29(3):2143-7. doi: 10.1007/s12032-011-0010-1. Epub 2011 Jun 30.

Abstract

Macrophage colony-stimulating factor (M-CSF) was recently implicated by in vitro studies as a survival and proliferation factor for Hodgkin/Reed-Sternberg cells. We evaluated pre-treatment serum M-CSF levels in 66 patients with histopathologic diagnosis of classical Hodgkin lymphoma (HL) and looked for possible correlations with baseline clinical characteristics. Significantly higher M-CSF serum concentrations were found in patients with bulky mediastinal mass, systemic symptoms, and elevated ESR but not LDH. There was no significant association between M-CSF level and sex, clinical stage, number of lymph node areas involved, and histopathological subtype of HL. We conclude that serum M-CSF levels are frequently elevated in HL patients and are significantly related to the presence of bulky mediastinal mass and systemic symptoms. These observations may indicate a pathogenetic role of M-CSF in Hodgkin lymphoma.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Biomarkers, Tumor / blood*
  • Female
  • Hodgkin Disease / blood*
  • Hodgkin Disease / pathology*
  • Humans
  • Macrophage Colony-Stimulating Factor / blood*
  • Male
  • Middle Aged
  • Neoplasm Staging
  • Prognosis
  • Young Adult

Substances

  • Biomarkers, Tumor
  • Macrophage Colony-Stimulating Factor