Synthesis of pyrido[1,2-b]indazoles via aryne [3 + 2] cycloaddition with N-tosylpyridinium imides

Jingjing Zhao; Chunrui Wu; Pan Li; Wenying Ai; Hongli Chen; Chaojie Wang; Richard C Larock; Feng Shi

doi:10.1021/jo200863e

Synthesis of pyrido[1,2-b]indazoles via aryne [3 + 2] cycloaddition with N-tosylpyridinium imides

J Org Chem. 2011 Aug 19;76(16):6837-43. doi: 10.1021/jo200863e. Epub 2011 Jul 26.

Authors

Jingjing Zhao¹, Chunrui Wu, Pan Li, Wenying Ai, Hongli Chen, Chaojie Wang, Richard C Larock, Feng Shi

Affiliation

¹ Key Laboratory of Natural Medicine and Immuno-Engineering of Henan Province, Henan University, Jinming Campus, Kaifeng, Henan 475004, P. R. China.

PMID: 21755977
DOI: 10.1021/jo200863e

Abstract

The [3 + 2] cycloaddition of arynes with N-tosylpyridinium imides, followed by an elimination of Ts(-), affords pyrido[1,2-b]indazoles under mild reaction conditions in good yields.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Catalysis
Cyclization
Imides / chemistry*
Indazoles / chemical synthesis*
Molecular Structure
Pyridinium Compounds / chemistry*
Stereoisomerism

Substances

Imides
Indazoles
Pyridinium Compounds