Preliminary reference intervals for cystatin C and beta-trace protein in preterm and term neonates

Erika Bariciak; Abeer Yasin; JoAnn Harrold; Mark Walker; Nathalie Lepage; Guido Filler

doi:10.1016/j.clinbiochem.2011.06.987

Preliminary reference intervals for cystatin C and beta-trace protein in preterm and term neonates

Clin Biochem. 2011 Sep;44(13):1156-1159. doi: 10.1016/j.clinbiochem.2011.06.987. Epub 2011 Jul 13.

Authors

Erika Bariciak¹, Abeer Yasin², JoAnn Harrold¹, Mark Walker³, Nathalie Lepage⁴, Guido Filler⁵

Affiliations

¹ Department of Pediatrics, University of Ottawa, Ottawa, ON, Canada K1H 8L1.
² Department of Pediatrics, Schulich School of Medicine & Dentistry, London, ON, Canada N6A 5W9.
³ Ottawa Hospital General Campus, University of Ottawa, ON, Canada K1H 8L6.
⁴ Department of Pathology and Laboratory Medicine, University of Ottawa, Ottawa, ON, Canada K1H 8L1.
⁵ Department of Pediatrics, Schulich School of Medicine & Dentistry, London, ON, Canada N6A 5W9; Department of Pathology and Laboratory Medicine, Schulich School of Medicine & Dentistry, University of Western Ontario, London, Ontario, Canada N5A 5A5. Electronic address: guido.filler@lhsc.on.ca.

PMID: 21771588
DOI: 10.1016/j.clinbiochem.2011.06.987

Abstract

Objective: To determine the reference intervals for serum cystatin C (CysC) and beta-trace protein (BTP) as markers of renal function in preterm and term neonates.

Design and methods: Blood samples of 128 neonates (34% female) admitted to the NICU were analyzed to determine the levels of serum creatinine (enzymatically), CysC and BTP (nephelometric, Siemens Health Care).

Results: The reference intervals, categorized by age, were reported for the 128 neonates. Median (lower/upper limit) BTP were 1.85 (0.57/3.16) and 1.27 (0.51/2.07) mg/L on days 1 and 3. In keeping with maturation of renal function after birth, CysC and BTP fell from days one to day three after birth, whereas creatinine did not.

Conclusion: Our data provides reference intervals for the levels of creatinine, CysC, and BTP in neonates on days 1 and 3 after birth and demonstrates that CysC and BTP reflect neonatal renal function, whereas creatinine reflects maternal renal function.

MeSH terms

Age Distribution
Creatinine
Cystatin C / blood*
Cystatin C / standards
Female
Humans
Infant, Newborn
Infant, Premature / blood*
Intramolecular Oxidoreductases / blood*
Intramolecular Oxidoreductases / standards
Lipocalins / blood*
Lipocalins / standards
Male
Reference Values

Substances

CST3 protein, human
Cystatin C
Lipocalins
Creatinine
Intramolecular Oxidoreductases
prostaglandin R2 D-isomerase