esBAF safeguards Stat3 binding to maintain pluripotency

Nat Cell Biol. 2011 Aug 1;13(8):886-8. doi: 10.1038/ncb2311.

Abstract

How the unique chromatin configuration of embryonic stem cells (ESCs) integrates inputs from exogenous stimuli to maintain pluripotency remains largely unknown. The ESC-specific ATP-dependent chromatin-remodelling (esBAF) complex maintains the accessibility of the target sites of Stat3, a leukaemia inhibitory factor (LIF) signalling effector, by preventing repressive localized polycomb-mediated trimethylation of Lys 27 of histone 3 (H3K27me3).

Publication types

  • Comment
  • News

MeSH terms

  • Adenosine Triphosphate / metabolism
  • Animals
  • Cell Differentiation
  • Chromatin Assembly and Disassembly
  • DNA Helicases / deficiency
  • DNA Helicases / genetics
  • DNA Helicases / metabolism
  • Embryonic Stem Cells / cytology*
  • Embryonic Stem Cells / metabolism*
  • Epigenesis, Genetic
  • Mice
  • Mice, Knockout
  • Models, Biological
  • Nuclear Proteins / deficiency
  • Nuclear Proteins / genetics
  • Nuclear Proteins / metabolism
  • Pluripotent Stem Cells / cytology*
  • Pluripotent Stem Cells / metabolism*
  • STAT3 Transcription Factor / metabolism*
  • Signal Transduction
  • Transcription Factors / deficiency
  • Transcription Factors / genetics
  • Transcription Factors / metabolism*

Substances

  • Nuclear Proteins
  • STAT3 Transcription Factor
  • Stat3 protein, mouse
  • Transcription Factors
  • Adenosine Triphosphate
  • Smarca4 protein, mouse
  • DNA Helicases