Comparative and stability analyses of 9- and 13-Oxo-octadecadienoic acids in various species of tomato

Haruya Takahashi; Young-Il Kim; Shizuka Hirai; Tsuyoshi Goto; Chie Ohyane; Taneaki Tsugane; Chiaki Konishi; Takashi Fujii; Shuji Inai; Yoko Iijima; Koh Aoki; Daisuke Shibata; Nobuyuki Takahashi; Teruo Kawada

doi:10.1271/bbb.110254

Comparative and stability analyses of 9- and 13-Oxo-octadecadienoic acids in various species of tomato

Biosci Biotechnol Biochem. 2011;75(8):1621-4. doi: 10.1271/bbb.110254. Epub 2011 Aug 7.

Authors

Haruya Takahashi¹, Young-Il Kim, Shizuka Hirai, Tsuyoshi Goto, Chie Ohyane, Taneaki Tsugane, Chiaki Konishi, Takashi Fujii, Shuji Inai, Yoko Iijima, Koh Aoki, Daisuke Shibata, Nobuyuki Takahashi, Teruo Kawada

Affiliation

¹ Laboratory of Molecular Functions of Food, Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Uji, Kyoto, Japan.

PMID: 21821922
DOI: 10.1271/bbb.110254

Abstract

Peroxisome proliferator-activated receptor-α (PPARα) regulates lipid metabolism. We have reported that tomato fruit contains 9-Oxo-(10E,12E)-octadecadienoic acid (9-Oxo-(10E,12E)-ODA), a PPARα agonist. In this study, we found that various tomato samples contained 9-Oxo-(10E,12Z)-ODA and its 13-Oxo-ODA isomers. Furthermore, several isomers showed structural stability under hot and acidic conditions.

Publication types

Comparative Study
Research Support, Non-U.S. Gov't

MeSH terms

Chromatography, Liquid
Drug Stability
Dyslipidemias / drug therapy
Dyslipidemias / physiopathology
Fatty Acids, Unsaturated* / chemistry
Fatty Acids, Unsaturated* / isolation & purification
Fatty Acids, Unsaturated* / pharmacology
Fruit / chemistry*
Isomerism
Lipid Metabolism / drug effects*
Magnetic Resonance Spectroscopy
Mass Spectrometry
PPAR alpha / agonists*
PPAR alpha / metabolism
Solanum lycopersicum / chemistry*

Substances

Fatty Acids, Unsaturated
PPAR alpha
octadecadienoic acid