Transforming growth factor β1 T868C gene polymorphism is associated with cerebral infarction in Japanese patients with type 2 diabetes

N Katakami; H Kaneto; T Osonoi; K Kawai; F Ishibashi; K Imamura; H Maegawa; A Kashiwagi; H Watada; R Kawamori; I Shimomura; Y Yamasaki

doi:10.1016/j.diabres.2011.08.005

Transforming growth factor β1 T868C gene polymorphism is associated with cerebral infarction in Japanese patients with type 2 diabetes

Diabetes Res Clin Pract. 2011 Dec;94(3):e57-60. doi: 10.1016/j.diabres.2011.08.005. Epub 2011 Aug 31.

Authors

N Katakami¹, H Kaneto, T Osonoi, K Kawai, F Ishibashi, K Imamura, H Maegawa, A Kashiwagi, H Watada, R Kawamori, I Shimomura, Y Yamasaki

Affiliation

¹ Department of Metabolic Medicine, Osaka University Graduate School of Medicine, 2-2, Yamadaoka, Suita, Osaka 565-0871, Japan. katakami@medone.med.osaka-u.ac.jp

PMID: 21885147
DOI: 10.1016/j.diabres.2011.08.005

Abstract

It is likely that the C allele of the polymorphism at position 29 of the translated sequence of transforming growth factor (TGF)-β1 gene, which codes a pleiotropic cytokine expressed in a variety of cells, is a susceptibility allele for cerebral infarction in Japanese type 2 diabetic patients.

MeSH terms

Asian People / genetics*
Cerebral Infarction / etiology*
Cohort Studies
Diabetes Complications / genetics*
Diabetes Mellitus, Type 2 / physiopathology*
Female
Genetic Predisposition to Disease
Genotype
Humans
Male
Middle Aged
Polymorphism, Genetic / genetics*
Prognosis
Transforming Growth Factor beta1 / genetics*

Substances

Transforming Growth Factor beta1