Abstract
The compound haliclonacyclamine A was isolated from the Haliclona sponge at Solomon Islands. It acts as a powerful in vitro and in vivo anti-plasmodial agent against the chloroquine-resistant Plasmodium falciparum strain FCB1and Plasmodium vinckei petteri-infected mice, respectively.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Cell Line, Tumor
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Female
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Haliclona / chemistry*
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Humans
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Macrocyclic Compounds / chemistry
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Macrocyclic Compounds / isolation & purification
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Macrocyclic Compounds / pharmacology*
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Macrocyclic Compounds / therapeutic use
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Magnetic Resonance Spectroscopy
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Malaria / drug therapy*
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Melanesia
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Mice
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Molecular Structure
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Piperidines / chemistry
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Piperidines / isolation & purification
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Piperidines / pharmacology*
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Piperidines / therapeutic use
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Plasmodium / drug effects*
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Survival Analysis
Substances
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Macrocyclic Compounds
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Piperidines
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haliclonacyclamine A