Abstract
We evaluated the possible association between trough linezolid (LZD) concentrations and platelet counts using a dose-response curve with a logit model equation. We demonstrated that trough LZD concentrations correlated with platelet counts. A significant decrease in platelet count was observed in patients with trough LZD concentrations higher than 22.1 μg/ml.
MeSH terms
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Acetamides / blood
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Acetamides / pharmacokinetics*
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Aged
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Aged, 80 and over
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Anti-Infective Agents / blood
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Anti-Infective Agents / pharmacokinetics*
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Dose-Response Relationship, Drug
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Female
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Humans
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Linezolid
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Male
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Middle Aged
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Oxazolidinones / blood
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Oxazolidinones / pharmacokinetics*
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Platelet Count
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Pneumonia / drug therapy
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Prospective Studies
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Thrombocytopenia / epidemiology*
Substances
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Acetamides
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Anti-Infective Agents
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Oxazolidinones
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Linezolid