Hierarchically structured nanocrystalline hydroxyapatite assembled hollow fibers as a promising protein delivery system

Liang Wu; Yuandong Dou; Kaili Lin; Wanyin Zhai; Wenguo Cui; Jiang Chang

doi:10.1039/c1cc14709a

Hierarchically structured nanocrystalline hydroxyapatite assembled hollow fibers as a promising protein delivery system

Chem Commun (Camb). 2011 Nov 14;47(42):11674-6. doi: 10.1039/c1cc14709a. Epub 2011 Sep 27.

Authors

Liang Wu¹, Yuandong Dou, Kaili Lin, Wanyin Zhai, Wenguo Cui, Jiang Chang

Affiliation

¹ State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050, China.

PMID: 21952504
DOI: 10.1039/c1cc14709a

Abstract

Nanocrystalline hydroxyapatite assembled hollow fibers (NHAHF) in the membrane form were fabricated by combining the electrospinning technique and the hydrothermal method. This novel hierarchical tubular structure of hydroxyapatite exhibited excellent protein loading capacity and long-term sustained release property.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Durapatite / chemistry*
Microscopy, Electron, Scanning
Microscopy, Electron, Transmission
Nanoparticles*
Recombinant Proteins / administration & dosage*

Substances

Recombinant Proteins
Durapatite