Hepatitis B virus X protein produced in Escherichia coli is biologically functional

J Virol. 1990 Aug;64(8):3963-6. doi: 10.1128/JVI.64.8.3963-3966.1990.

Abstract

The hepatitis B virus X gene product trans activates transcription from a variety of viral and cellular regulatory elements. We expressed the complete, nonfused X protein in Escherichia coli and showed it to be active in trans activating a human immunodeficiency virus long terminal repeat-linked chloramphenicol acetyltransferase reporter gene.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Chloramphenicol O-Acetyltransferase / genetics
  • Chloramphenicol O-Acetyltransferase / metabolism
  • Cloning, Molecular
  • Escherichia coli / genetics*
  • Gene Expression
  • HIV / genetics
  • Hepatitis B virus / genetics*
  • Plasmids
  • Recombinant Fusion Proteins / metabolism
  • Recombinant Proteins / isolation & purification
  • Recombinant Proteins / metabolism
  • Repetitive Sequences, Nucleic Acid
  • Restriction Mapping
  • Trans-Activators / genetics
  • Trans-Activators / isolation & purification
  • Trans-Activators / metabolism*
  • Transcriptional Activation
  • Viral Regulatory and Accessory Proteins

Substances

  • Recombinant Fusion Proteins
  • Recombinant Proteins
  • Trans-Activators
  • Viral Regulatory and Accessory Proteins
  • hepatitis B virus X protein
  • Chloramphenicol O-Acetyltransferase