Magnetic mesoporous carbonated hydroxyapatite microspheres with hierarchical nanostructure for drug delivery systems

Ya-Ping Guo; Li-Hua Guo; Yong-bo Yao; Cong-Qin Ning; Ya-Jun Guo

doi:10.1039/c1cc15190h

Magnetic mesoporous carbonated hydroxyapatite microspheres with hierarchical nanostructure for drug delivery systems

Chem Commun (Camb). 2011 Nov 28;47(44):12215-7. doi: 10.1039/c1cc15190h. Epub 2011 Oct 14.

Authors

Ya-Ping Guo¹, Li-Hua Guo, Yong-bo Yao, Cong-Qin Ning, Ya-Jun Guo

Affiliation

¹ State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, China.

PMID: 21998826
DOI: 10.1039/c1cc15190h

Abstract

Magnetic mesoporous carbonated hydroxyapatite microspheres have been fabricated hydrothermally by using CaCO(3)/Fe(3)O(4) microspheres as sacrificial templates. The high drug-loading capacity and sustained drug release property suggest that the multifunctional microspheres have great potentials for bone-implantable drug-delivery applications.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Biocompatible Materials / chemistry
Calcium Carbonate / chemistry*
Drug Carriers*
Durapatite / chemistry*
Ferrosoferric Oxide / chemistry*
Magnets
Microscopy, Electron, Scanning
Microspheres*
Nanostructures / chemistry
Nanostructures / ultrastructure
Porosity
Vancomycin / chemistry
X-Ray Diffraction

Substances

Biocompatible Materials
Drug Carriers
Vancomycin
Durapatite
Calcium Carbonate
Ferrosoferric Oxide