"Mycobacterium tilburgii" infection in two immunocompromised children: importance of molecular tools in culture-negative mycobacterial disease diagnosis

J Clin Microbiol. 2011 Dec;49(12):4409-11. doi: 10.1128/JCM.05460-11. Epub 2011 Oct 19.

Abstract

"Mycobacterium tilburgii" is a nontuberculous mycobacterium that cannot be cultured by current techniques. It is described as causing disseminated disease in adults. We present the first cases of disseminated disease in 2 immunocompromised children. This paper stresses the importance of molecular techniques for correct mycobacterial identification and guidance to immunological diagnosis.

Publication types

  • Case Reports

MeSH terms

  • Bacteriological Techniques / methods*
  • Child
  • Child, Preschool
  • DNA, Bacterial / chemistry
  • DNA, Bacterial / genetics
  • DNA, Ribosomal / chemistry
  • DNA, Ribosomal / genetics
  • Humans
  • Immunocompromised Host
  • Male
  • Molecular Diagnostic Techniques / methods*
  • Molecular Sequence Data
  • Mycobacterium / genetics
  • Mycobacterium / isolation & purification*
  • Mycobacterium Infections / diagnosis*
  • Mycobacterium Infections / microbiology
  • RNA, Ribosomal, 16S / genetics
  • Sequence Analysis, DNA

Substances

  • DNA, Bacterial
  • DNA, Ribosomal
  • RNA, Ribosomal, 16S

Associated data

  • GENBANK/HM069330
  • GENBANK/HM588695