True microbiota involved in chronic lung infection of cystic fibrosis patients found by culturing and 16S rRNA gene analysis

J Clin Microbiol. 2011 Dec;49(12):4352-5. doi: 10.1128/JCM.06092-11. Epub 2011 Oct 19.

Abstract

Patients suffering from cystic fibrosis (CF) develop chronic lung infection. In this study, we investigated the microorganisms present in transplanted CF lungs (n = 5) by standard culturing and 16S rRNA gene analysis. A correspondence between culturing and the molecular methods was observed. In conclusion, standard culturing seems reliable for the identification of the dominating pathogens.

MeSH terms

  • Bacteria / classification*
  • Bacteria / genetics
  • Bacteria / isolation & purification*
  • Biodiversity*
  • Bronchopneumonia / microbiology*
  • Chronic Disease
  • Cluster Analysis
  • Cystic Fibrosis / complications*
  • DNA, Bacterial / chemistry
  • DNA, Bacterial / genetics
  • DNA, Ribosomal / chemistry
  • DNA, Ribosomal / genetics
  • Humans
  • Molecular Sequence Data
  • Phylogeny
  • RNA, Ribosomal, 16S / genetics
  • Sequence Analysis, DNA

Substances

  • DNA, Bacterial
  • DNA, Ribosomal
  • RNA, Ribosomal, 16S

Associated data

  • GENBANK/JN802672
  • GENBANK/JN802673
  • GENBANK/JN802674
  • GENBANK/JN802675
  • GENBANK/JN802676
  • GENBANK/JN802677
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  • GENBANK/JN802681
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  • GENBANK/JN802684
  • GENBANK/JN802685
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  • GENBANK/JN802687
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  • GENBANK/JN802690
  • GENBANK/JN802691
  • GENBANK/JN802692
  • GENBANK/JN802693
  • GENBANK/JN802694
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  • GENBANK/JN802696
  • GENBANK/JN802697
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  • GENBANK/JN802699
  • GENBANK/JN802700
  • GENBANK/JN802701
  • GENBANK/JN802702
  • GENBANK/JN802703
  • GENBANK/JN802704