Stimulation of p21ras upon T-cell activation

J Downward; J D Graves; P H Warne; S Rayter; D A Cantrell

doi:10.1038/346719a0

Stimulation of p21ras upon T-cell activation

Nature. 1990 Aug 23;346(6286):719-23. doi: 10.1038/346719a0.

Authors

J Downward¹, J D Graves, P H Warne, S Rayter, D A Cantrell

Affiliation

¹ Signal Transduction Laboratory, Imperial Cancer Research Fund, Lincoln's Inn Fields, London, UK.

PMID: 2201921
DOI: 10.1038/346719a0

Abstract

External signals that control the activity of proteins encoded by the ras proto-oncogenes have not previously been characterized. It is now shown that stimulation of the antigen receptor of T lymphocytes causes a rapid activation of p21ras. The mechanism seems to involve a decrease in the activity of GAP, the GTPase-activating protein, on stimulation of protein kinase C. In lymphocytes, p21ras may therefore be an important mediator of the action of protein kinase C.

MeSH terms

GTPase-Activating Proteins
Genes, ras*
Humans
In Vitro Techniques
Kinetics
Lymphocyte Activation
Oncogene Protein p21(ras) / genetics*
Oncogene Protein p21(ras) / metabolism
Protein Kinase C / metabolism
Proteins / metabolism*
Receptors, Antigen, T-Cell / immunology
Signal Transduction
T-Lymphocytes / enzymology
T-Lymphocytes / immunology*
ras GTPase-Activating Proteins

Substances

GTPase-Activating Proteins
Proteins
Receptors, Antigen, T-Cell
ras GTPase-Activating Proteins
Protein Kinase C
Oncogene Protein p21(ras)