X-ray computed tomography imaging of breast cancer by using targeted peptide-labeled bismuth sulfide nanoparticles

Angew Chem Int Ed Engl. 2011 Dec 16;50(51):12308-11. doi: 10.1002/anie.201104507. Epub 2011 Oct 26.

Abstract

Enhanced visualization of breast cancer using X-ray microComputed Tomography is achieved using 10nm-diameter Bi2S3 nanoparticles, modified to display a tumor homing peptide (LyP-1, CGNKRTRGC). Accumulation within the tumor was increased by 260% over non-labeled nanoparticles.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Bismuth / analysis
  • Bismuth / chemistry*
  • Bismuth / pharmacokinetics
  • Breast Neoplasms / diagnostic imaging*
  • Breast Neoplasms / metabolism
  • Cell Line, Tumor
  • Female
  • Humans
  • Mice
  • Nanoparticles / analysis
  • Nanoparticles / chemistry*
  • Sulfides / analysis
  • Sulfides / chemistry*
  • Sulfides / pharmacokinetics
  • Tomography, X-Ray Computed / methods*

Substances

  • Sulfides
  • Bismuth
  • bismuth sulfide