Abstract
Fifteen limonoids, meliatoosenins E-S (1-15), and 10 known compounds were isolated from the fruits of Melia toosendan. Their structures were elucidated on the basis of extensive spectroscopic methods including DEPT, HSQC, HMBC, (1)H-(1)H COSY, and ROESY experiments. All the compounds were evaluated for antiproliferative activity using A-549 and HL-60 cell lines.
Copyright © 2011 Elsevier Ltd. All rights reserved.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Antineoplastic Agents, Phytogenic / chemistry
-
Antineoplastic Agents, Phytogenic / isolation & purification*
-
Antineoplastic Agents, Phytogenic / pharmacology
-
Drug Screening Assays, Antitumor
-
Drugs, Chinese Herbal / chemistry
-
Drugs, Chinese Herbal / isolation & purification*
-
Drugs, Chinese Herbal / pharmacology
-
Fruit / chemistry
-
HL-60 Cells
-
Humans
-
Limonins / chemistry
-
Limonins / isolation & purification*
-
Limonins / pharmacology
-
Melia / chemistry
-
Molecular Structure
-
Nuclear Magnetic Resonance, Biomolecular
Substances
-
Antineoplastic Agents, Phytogenic
-
Drugs, Chinese Herbal
-
Limonins