Mammalian O6-alkylguanine-DNA alkyltransferase: regulation and importance in response to alkylating carcinogenic and therapeutic agents

Cancer Res. 1990 Oct 1;50(19):6119-29.
No abstract available

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Alkylating Agents / toxicity*
  • Alkylation
  • Animals
  • Cells, Cultured / enzymology
  • DNA / drug effects
  • DNA Repair*
  • Enzyme Induction
  • Escherichia coli / enzymology
  • Gene Expression Regulation, Enzymologic / genetics
  • Humans
  • Methylation
  • Methyltransferases / biosynthesis
  • Methyltransferases / isolation & purification
  • Methyltransferases / metabolism*
  • O(6)-Methylguanine-DNA Methyltransferase
  • Phenotype
  • Substrate Specificity
  • Terminology as Topic
  • Transfection

Substances

  • Alkylating Agents
  • DNA
  • Methyltransferases
  • O(6)-Methylguanine-DNA Methyltransferase