Ratiometric fluorescence imaging for distinguishing chloride concentration between normal and ischemic ventricular myocytes

Ping Li; Ting Xie; Nannan Fan; Kexiang Li; Bo Tang

doi:10.1039/c1cc15258k

Ratiometric fluorescence imaging for distinguishing chloride concentration between normal and ischemic ventricular myocytes

Chem Commun (Camb). 2012 Feb 18;48(15):2077-9. doi: 10.1039/c1cc15258k. Epub 2011 Nov 7.

Authors

Ping Li¹, Ting Xie, Nannan Fan, Kexiang Li, Bo Tang

Affiliation

¹ College of Chemistry, Chemical Engineering and Materials Science, Engineering Research Center of Pesticide and Medicine Intermediate Clean Production, Key Laboratory of Molecular and Nano Probes, Ministry of Education, Shandong Normal University, Jinan 250014, PR China.

PMID: 22057128
DOI: 10.1039/c1cc15258k

Abstract

We devised a new ratiometric fluorescent probe for the detection of chloride ions. This synthesized probe was applied to the ventricular myocytes to successfully realize dynamic imaging of Cl(-) concentration fluctuations during the myocardial ischemia course.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Chlorides / analysis*
Fluoresceins / chemistry
Fluorescence
Fluorescent Dyes / chemistry*
Heart Ventricles / cytology*
Heart Ventricles / pathology
Humans
Microscopy, Confocal
Myocardial Ischemia / metabolism*
Myocardial Ischemia / pathology
Myocytes, Cardiac / cytology*
Myocytes, Cardiac / pathology
Quinolines / chemistry

Substances

Chlorides
Fluoresceins
Fluorescent Dyes
Quinolines
5-aminofluorescein
6-methoxyquinoline