Radiologic features of NUT midline carcinoma in an adolescent

Pediatr Radiol. 2012 Feb;42(2):249-52. doi: 10.1007/s00247-011-2288-8. Epub 2011 Nov 6.

Abstract

We present a case of NUT midline carcinoma (NMC) mimicking lymphoma in an adolescent boy, with attention to multidetector CT appearance and pattern of metastasis on [F-18]2-fluoro-2-deoxyglucose positron emission tomography (FDG PET/CT). Few case reports have focused on the imaging characteristics of this rare tumor in the pediatric imaging literature. A newly described but increasingly recognized disease entity, NMC should enter the differential of pediatric midline tumors displaying particularly aggressive characteristics on imaging.

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use
  • Carcinoma / diagnostic imaging*
  • Carcinoma / drug therapy
  • Diagnosis, Differential
  • Fatal Outcome
  • Fluorodeoxyglucose F18
  • Humans
  • Immunohistochemistry
  • In Situ Hybridization, Fluorescence
  • Male
  • Mediastinal Neoplasms / diagnostic imaging*
  • Mediastinal Neoplasms / drug therapy
  • Multimodal Imaging*
  • Neoplasm Proteins
  • Nuclear Proteins
  • Oncogene Proteins
  • Positron-Emission Tomography*
  • Radiopharmaceuticals
  • Tomography, X-Ray Computed*
  • Whole Body Imaging

Substances

  • NUTM1 protein, human
  • Neoplasm Proteins
  • Nuclear Proteins
  • Oncogene Proteins
  • Radiopharmaceuticals
  • Fluorodeoxyglucose F18