[Association between polymorphisms of interleukin-6 gene promoter and breast cancer]

Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2011 Nov;27(11):1220-2.
[Article in Chinese]

Abstract

Aim: To study possible association between three single nucleotide polymorphisms (-597G/A, -572C/G and -174G/C) of interleukin-6 (IL-6) gene promoter and breast cancer.

Methods: Genomic DNA was isolated from the venous blood leukocytes from 176 unrelated patients with breast cancer and 200 healthy unrelated females (control group). Polymorphisms of -597G/A, -572C/G and -174G/C, were genotyped by PCR-restriction fragment length polymorphisms (PCR-RFLP). SPSS 11.5 software was employed for statistical analysis and the association of IL-6 polymorphisms with breast cancer was evaluated by x(2); test.

Results: There was significant differences in both allele and genotype frequencies of -572C/G in case group compared with control group. The allele G of -572C/G was significantly higher in cancer patients than the controls(x(2);=15.438, P<0.01).

Conclusion: There is an association between -572C/G polymorphism and breast cancer risk. The females with G allele of -572C/G are susceptible to breast cancer compared with non-carrying females.

Publication types

  • English Abstract

MeSH terms

  • Adult
  • Aged
  • Alleles*
  • Breast Neoplasms / genetics*
  • Breast Neoplasms / metabolism
  • Female
  • Gene Frequency
  • Genetic Predisposition to Disease / genetics*
  • Humans
  • Interleukin-6 / blood
  • Interleukin-6 / genetics*
  • Middle Aged
  • Polymorphism, Single Nucleotide / genetics*
  • Promoter Regions, Genetic / genetics*
  • Retrospective Studies

Substances

  • Interleukin-6