Mollenyne A, a long-chain chlorodibromohydrin amide from the sponge Spirastrella mollis

Org Lett. 2011 Dec 16;13(24):6338-41. doi: 10.1021/ol2024778. Epub 2011 Nov 16.

Abstract

The structure of mollenyne A, a cytotoxic nitrogenous halogenated long-chain carboxamide from the sponge Spirastrella mollis, was elucidated by integrated spectroscopic analysis, including CD, and chemical conversion.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Amides / chemistry
  • Amides / isolation & purification*
  • Amides / pharmacology
  • Animals
  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / isolation & purification*
  • Antineoplastic Agents / pharmacology
  • Circular Dichroism
  • Drug Screening Assays, Antitumor
  • HCT116 Cells
  • Humans
  • Hydrocarbons, Halogenated / chemistry
  • Hydrocarbons, Halogenated / isolation & purification*
  • Hydrocarbons, Halogenated / pharmacology
  • Lipids / chemistry
  • Lipids / isolation & purification*
  • Lipids / pharmacology
  • Molecular Structure
  • Nuclear Magnetic Resonance, Biomolecular
  • Porifera / chemistry*

Substances

  • Amides
  • Antineoplastic Agents
  • Hydrocarbons, Halogenated
  • Lipids
  • mollenyne A