Hydroxyureas as noncovalent proteasome inhibitors

Angew Chem Int Ed Engl. 2012 Jan 2;51(1):247-9. doi: 10.1002/anie.201106010. Epub 2011 Nov 21.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Binding Sites
  • Catalytic Domain
  • Crystallography, X-Ray
  • Drug Design
  • Hydrogen Bonding
  • Hydroxyurea / chemistry*
  • Protease Inhibitors / chemistry*
  • Proteasome Endopeptidase Complex / metabolism
  • Proteasome Inhibitors*
  • Protein Structure, Tertiary

Substances

  • Protease Inhibitors
  • Proteasome Inhibitors
  • Proteasome Endopeptidase Complex
  • Hydroxyurea