Synthesis and biological evaluation of molecular probes based on the 9-methylstreptimidone derivative DTCM-glutarimide

Bioorg Med Chem Lett. 2012 Jan 1;22(1):164-7. doi: 10.1016/j.bmcl.2011.11.045. Epub 2011 Nov 18.

Abstract

Molecular probes based on 3-[(dodecylthiocarbonyl)methyl]glutarimide (DTCM-glutarimide) were synthesized and assessed for inhibitory activity against LPS-induced NO production. Among the probes examined, several derivatives exhibited potential for use in determining the target proteins of DTCM-glutarimide.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Biotinylation
  • Cell Line
  • Chemistry, Pharmaceutical / methods
  • Drug Design
  • Humans
  • Jurkat Cells
  • Lipopolysaccharides / chemistry
  • Lipopolysaccharides / pharmacology
  • Mice
  • Models, Chemical
  • Molecular Probes / chemistry
  • NF-kappa B / metabolism
  • Nitric Oxide / chemistry
  • Piperidones / chemical synthesis
  • Piperidones / pharmacology*
  • Time Factors

Substances

  • 3-((dodecylthiocarbonyl)methyl)glutarimide
  • Lipopolysaccharides
  • Molecular Probes
  • NF-kappa B
  • Piperidones
  • Nitric Oxide
  • 9-methylstreptimidone
  • glutarimide