Abstract
Herpes simplex virus type 1 latency in trigeminal ganglia (TG) is accompanied by a chronic immune cell infiltration. The aim of this study was to analyse the T-cell receptor β-chain repertoire in latently HSV-1 infected human TG. Using complementarity-determining region 3 spectratyping, 74 expanded β-chain sequences were identified in five TG. No clone appeared in more than one subject. Similar clones were present in the right and the left TG of two subjects. This indicates that these T cells are primed in the periphery and recognise the same antigen in the TG of both sides.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adolescent
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Adult
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Aged
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Amino Acid Sequence
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Autopsy
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CD8-Positive T-Lymphocytes / immunology
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CD8-Positive T-Lymphocytes / virology*
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Cell Movement / immunology
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Cell Proliferation
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Clone Cells / immunology
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Clone Cells / virology
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Complementarity Determining Regions / genetics
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Complementarity Determining Regions / immunology
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Female
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Herpes Simplex / immunology
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Herpes Simplex / virology*
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Herpesvirus 1, Human / physiology*
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Humans
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Immunophenotyping
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Male
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Middle Aged
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Molecular Sequence Data
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Receptors, Antigen, T-Cell, alpha-beta / biosynthesis
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Receptors, Antigen, T-Cell, alpha-beta / immunology
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Trigeminal Ganglion / immunology
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Trigeminal Ganglion / virology*
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Virus Latency / immunology*
Substances
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Complementarity Determining Regions
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Receptors, Antigen, T-Cell, alpha-beta