Detection of mobile-genetic-element variation between colonizing and infecting hospital-associated methicillin-resistant Staphylococcus aureus isolates

J Clin Microbiol. 2012 Mar;50(3):1073-5. doi: 10.1128/JCM.05938-11. Epub 2011 Dec 14.

Abstract

Whole-genome analysis by 62-strain microarray showed variation in resistance and virulence genes on mobile genetic elements (MGEs) between 40 isolates of methicillin-resistant Staphylococcus aureus (MRSA) strain CC22-SCCmecIV but also showed (i) detection of two previously unrecognized MRSA transmission events and (ii) that 7/8 patients were infected with a variant of their own colonizing isolate.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Carrier State / microbiology*
  • Drug Resistance, Bacterial
  • Genetic Variation*
  • Genome, Bacterial
  • Genotype
  • Hospitals
  • Humans
  • Interspersed Repetitive Sequences*
  • Methicillin-Resistant Staphylococcus aureus / drug effects
  • Methicillin-Resistant Staphylococcus aureus / genetics*
  • Methicillin-Resistant Staphylococcus aureus / isolation & purification
  • Methicillin-Resistant Staphylococcus aureus / pathogenicity
  • Microarray Analysis
  • Molecular Epidemiology
  • Molecular Typing
  • Staphylococcal Infections / microbiology*
  • Virulence Factors / genetics

Substances

  • Virulence Factors