Gemella morbillorum bacteremia after anti-tumor necrosis factor alpha as acne inversa therapy

J Clin Microbiol. 2012 Mar;50(3):1109-12. doi: 10.1128/JCM.06161-11. Epub 2011 Dec 21.

Abstract

We present a case of fever, brain abscesses, and Gemella morbillorum bacteremia after anti-tumor necrosis factor alpha (TNF-α) therapy in a 21-year-old acne inversa patient currently taking long-term dapsone. To the best of our knowledge, this is the first report describing such a case. During antimicrobial therapy, the patient developed systemic varicella infection with severe thrombocytopenia.

Publication types

  • Case Reports

MeSH terms

  • Anti-Infective Agents / administration & dosage
  • Antibodies / administration & dosage
  • Antibodies / adverse effects*
  • Bacteremia / complications
  • Bacteremia / diagnosis*
  • Bacteremia / microbiology
  • Brain Abscess / diagnosis
  • Brain Abscess / microbiology
  • Dapsone / administration & dosage
  • Gemella / isolation & purification*
  • Gram-Positive Bacterial Infections / diagnosis*
  • Gram-Positive Bacterial Infections / microbiology
  • Hidradenitis Suppurativa / complications
  • Hidradenitis Suppurativa / drug therapy*
  • Humans
  • Immunologic Factors / administration & dosage
  • Immunologic Factors / adverse effects*
  • Male
  • Tumor Necrosis Factor-alpha / antagonists & inhibitors*
  • Young Adult

Substances

  • Anti-Infective Agents
  • Antibodies
  • Immunologic Factors
  • Tumor Necrosis Factor-alpha
  • Dapsone