Thymidine auxotrophic Staphylococcus aureus small-colony variant endocarditis and left ventricular assist device infection

Awele Maduka-Ezeh; Maria Teresa Seville; Shimon Kusne; Holenarasipur R Vikram; Janis E Blair; Kerryl Greenwood-Quaintance; Francisco Arabia; Robin Patel

doi:10.1128/JCM.01170-11

Thymidine auxotrophic Staphylococcus aureus small-colony variant endocarditis and left ventricular assist device infection

J Clin Microbiol. 2012 Mar;50(3):1102-5. doi: 10.1128/JCM.01170-11. Epub 2012 Jan 11.

Authors

Awele Maduka-Ezeh¹, Maria Teresa Seville, Shimon Kusne, Holenarasipur R Vikram, Janis E Blair, Kerryl Greenwood-Quaintance, Francisco Arabia, Robin Patel

Affiliation

¹ Division of Infectious Diseases, Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota, USA.

Abstract

We describe a thymidine-dependent small-colony variant of Staphylococcus aureus associated with left ventricular assist device infection and prosthetic valve and pacemaker endocarditis.

Publication types

Case Reports

MeSH terms

Adult
Anti-Bacterial Agents / pharmacology
Anti-Bacterial Agents / therapeutic use
Endocarditis, Bacterial / diagnosis*
Endocarditis, Bacterial / microbiology
Female
Heart Valves / microbiology
Humans
Microbial Sensitivity Tests
Pacemaker, Artificial / microbiology
Prosthesis-Related Infections / diagnosis*
Prosthesis-Related Infections / microbiology
Staphylococcal Infections / diagnosis*
Staphylococcal Infections / microbiology
Staphylococcus aureus / genetics
Staphylococcus aureus / growth & development
Staphylococcus aureus / isolation & purification*
Staphylococcus aureus / metabolism*
Thymidine / deficiency*

Substances

Anti-Bacterial Agents
Thymidine