Abstract
Six new diterpenoids, sabiperones A-F (1-6) have been isolated from the aerial part of Juniperus sabina. Their structures were elucidated by spectroscopic methods including 2D NMR techniques. Sabiperone F showed moderate cell growth inhibitory activities against five human cancer cell lines.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents, Phytogenic / chemistry*
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Antineoplastic Agents, Phytogenic / isolation & purification
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Antineoplastic Agents, Phytogenic / pharmacology
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Cell Line, Tumor
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Cell Proliferation / drug effects
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Diterpenes / chemistry*
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Diterpenes / isolation & purification
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Diterpenes / pharmacology
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Drug Screening Assays, Antitumor
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Humans
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Juniperus / chemistry*
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Magnetic Resonance Spectroscopy
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Molecular Conformation
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Plant Components, Aerial / chemistry
Substances
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Antineoplastic Agents, Phytogenic
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Diterpenes