Abstract
The hemopoiesis-stimulating effect of combined treatment with immobilized oligonucleotides and hyaluronidase preparations was studied during cytostatic-induced myelosuppression caused by cyclophosphamide administration. Immobilized hyaluronidase was shown to increase the efficiency of correction of changes in the erythroid and granulocytic hemopoietic stems with immobilized oligonucleotides. This potentiation of the effect of immobilized oligonucleotides by immobilized hyaluronidase was related to an increase in functional activity of committed hemopoietic precursors.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Bone Marrow / drug effects
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Cell Differentiation / drug effects*
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Cyclophosphamide / adverse effects
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Cyclophosphamide / pharmacology
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Cytostatic Agents / pharmacology
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Enzymes, Immobilized / pharmacology
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Erythroid Cells / drug effects
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Erythroid Cells / metabolism
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Granulocyte Colony-Stimulating Factor
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Granulocytes / drug effects
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Granulocytes / metabolism
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Hematopoiesis / drug effects*
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Hematopoietic Stem Cells / drug effects
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Hematopoietic Stem Cells / metabolism*
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Hyaluronoglucosaminidase / pharmacology*
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Mice
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Mice, Inbred CBA
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Oligonucleotides / pharmacology*
Substances
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Cytostatic Agents
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Enzymes, Immobilized
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Oligonucleotides
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Granulocyte Colony-Stimulating Factor
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Cyclophosphamide
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Hyaluronoglucosaminidase