Alzheimer's disease risk factor complement receptor 1 is associated with depression

Neurosci Lett. 2012 Feb 21;510(1):6-9. doi: 10.1016/j.neulet.2011.12.059. Epub 2012 Jan 8.

Abstract

Variation in the complement receptor 1 gene (CR1) has been identified in recent genome-wide association studies as a risk factor for Alzheimer's disease. Here, we show that two Alzheimer's disease-associated CR1 variants, rs6656401 and rs3818361, are associated with major recurrent depression in females in a population-based cohort using individuals from the Generation Scotland: Scottish Family Health Study.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alzheimer Disease / complications
  • Alzheimer Disease / genetics*
  • Depression / complications
  • Depression / genetics*
  • Female
  • Genetic Predisposition to Disease / genetics*
  • Genome-Wide Association Study
  • Haplotypes / genetics
  • Humans
  • Male
  • Polymorphism, Single Nucleotide / genetics
  • Receptors, Complement / genetics*
  • Scotland

Substances

  • Receptors, Complement