Candida spp. with acquired echinocandin resistance, France, 2004-2010

Emerg Infect Dis. 2012 Jan;18(1):86-90. doi: 10.3201/eid1801.110556.

Abstract

We report 20 episodes of infection caused by acquired echinocandin-resistant Candida spp. harboring diverse and new Fksp mutations. For 12 patients, initial isolates (low MIC, wild-type Fksp sequence) and subsequent isolates (after caspofungin treatment, high MIC, mutated Fksp) were genetically related.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Antifungal Agents / pharmacology*
  • Candida / classification
  • Candida / drug effects*
  • Candidiasis / epidemiology*
  • Candidiasis / microbiology*
  • Drug Resistance, Fungal
  • Echinocandins / pharmacology*
  • Female
  • France / epidemiology
  • Humans
  • Male
  • Microbial Sensitivity Tests
  • Middle Aged
  • Young Adult

Substances

  • Antifungal Agents
  • Echinocandins