Olanzapine-induced eccrine squamous syringometaplasia

Am J Dermatopathol. 2012 Jun;34(4):434-7. doi: 10.1097/DAD.0b013e31823812f1.

Abstract

Eccrine squamous syringometaplasia is a histopathologic pattern that has mainly been described in patients receiving chemotherapy. Its association to nonchemotherapeutic agents is rare, with very few cases reported in the literature. We present the case of a 55-year-old patient with schizophrenia, who developed a skin eruption 5 weeks after initiating treatment with olanzapine. The histopathologic study revealed squamous syringometaplasia of the dermal eccrine ducts.

Publication types

  • Case Reports

MeSH terms

  • Antipsychotic Agents / adverse effects*
  • Benzodiazepines / adverse effects*
  • Biopsy
  • Dermatologic Agents / therapeutic use
  • Drug Substitution
  • Eccrine Glands / drug effects*
  • Eccrine Glands / pathology
  • Humans
  • Male
  • Metaplasia
  • Middle Aged
  • Olanzapine
  • Risperidone / therapeutic use
  • Schizophrenia / drug therapy*
  • Sweat Gland Neoplasms / chemically induced*
  • Sweat Gland Neoplasms / drug therapy
  • Sweat Gland Neoplasms / pathology
  • Treatment Outcome

Substances

  • Antipsychotic Agents
  • Dermatologic Agents
  • Benzodiazepines
  • Risperidone
  • Olanzapine