Synthetic approaches to the 2010 new drugs

Kevin K-C Liu; Subas M Sakya; Christopher J O'Donnell; Andrew C Flick; Hong X Ding

doi:10.1016/j.bmc.2011.12.049

Synthetic approaches to the 2010 new drugs

Bioorg Med Chem. 2012 Feb 1;20(3):1155-74. doi: 10.1016/j.bmc.2011.12.049. Epub 2012 Jan 2.

Authors

Kevin K-C Liu¹, Subas M Sakya, Christopher J O'Donnell, Andrew C Flick, Hong X Ding

Affiliation

¹ Pfizer Inc., La Jolla, CA 92037, USA. Kevin.k.liu@pfizer.com

PMID: 22261026
DOI: 10.1016/j.bmc.2011.12.049

Abstract

New drugs are introduced to the market every year and each represents a privileged structure for its biological target. These new chemical entities (NCEs) provide insights into molecular recognition and also serve as leads for designing future new drugs. This review covers the synthesis of 15 NCEs that were launched anywhere in the world in 2010.

Publication types

Review

MeSH terms

Chemistry Techniques, Synthetic / methods*
Drug Design*
Molecular Structure
Pharmaceutical Preparations / chemical synthesis*
Pharmaceutical Preparations / chemistry

Substances

Pharmaceutical Preparations