Synthesis of benzisoxazolines by the coupling of arynes with nitrones

J Org Chem. 2012 Mar 2;77(5):2279-84. doi: 10.1021/jo2025064. Epub 2012 Feb 16.

Abstract

A variety of substituted benzisoxazolines have been synthesized by the [3 + 2] cycloaddition of nitrones and arynes. The reaction scope is broad, the reaction conditions are mild, and the process tolerates a variety of functional groups.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Benzene Derivatives / chemistry*
  • Cyclization
  • Isoxazoles / chemical synthesis*
  • Isoxazoles / chemistry
  • Molecular Structure
  • Nitrogen Oxides / chemistry*
  • Stereoisomerism

Substances

  • Benzene Derivatives
  • Isoxazoles
  • Nitrogen Oxides
  • benzyne
  • nitrones