A novel view of paroxysmal nocturnal hemoglobinuria pathogenesis: more motile PNH hematopoietic stem/progenitor cells displace normal HSPCs from their niches in bone marrow due to defective adhesion, enhanced migration and mobilization in response to erythrocyte-released sphingosine-1 phosphate gradient

Leukemia. 2012 Jul;26(7):1722-5. doi: 10.1038/leu.2012.46. Epub 2012 Feb 20.
No abstract available

Publication types

  • Comparative Study
  • Letter
  • Research Support, N.I.H., Extramural

MeSH terms

  • Adult
  • Aged
  • Bone Marrow / metabolism
  • Bone Marrow / pathology*
  • Cell Adhesion*
  • Cell Movement*
  • Cells, Cultured
  • Erythrocytes / cytology
  • Erythrocytes / metabolism*
  • Hematopoietic Stem Cell Mobilization
  • Hematopoietic Stem Cells / pathology*
  • Hemoglobinuria, Paroxysmal / metabolism
  • Hemoglobinuria, Paroxysmal / pathology*
  • Humans
  • Lysophospholipids / metabolism*
  • Middle Aged
  • Sphingosine / analogs & derivatives*
  • Sphingosine / metabolism
  • Young Adult

Substances

  • Lysophospholipids
  • sphingosine 1-phosphate
  • Sphingosine