7q-and loss of a polymorphism for the met oncogene in a patient with myelofibrosis

G Rege-Cambrin; A Guerrasio; A Serra; A Alfarano; A Stacchini; P Lusso; G Benetton; M Aglietta; M Bonetto; G Saglio

doi:10.1007/BF00351120

7q-and loss of a polymorphism for the met oncogene in a patient with myelofibrosis

Cytotechnology. 1987 Oct;1(1):37-40. doi: 10.1007/BF00351120.

Authors

G Rege-Cambrin¹, A Guerrasio, A Serra, A Alfarano, A Stacchini, P Lusso, G Benetton, M Aglietta, M Bonetto, G Saglio

Affiliation

¹ Dipartimento di Scienze Biomediche e Oncologia Umana, University of Turin, Via Genova 3, 10126, Torino, Italy.

PMID: 22358438
DOI: 10.1007/BF00351120

Abstract

The met oncogene is the normal counterpart of a chemically-induced transforming gene. The chromosomal localization of met is 7q21-31. In a patient with myelofibrosis and an interstitial deletion on 7q, we demonstrate that a Taq I polymorphism for the met oncogene is lost in the neoplastic cells, thus indicating that the deletion occuring in the long arm of chromosome 7 involves the met locus.