Abstract
Bacterial vaginosis (BV) and Trichomonas vaginalis (TV) infections are both very common and are associated with increased risk of sexual transmission of HIV. There are several mechanisms by which BV and TV could affect susceptibility including inducing pro-inflammatory cytokines and disrupting mucosal barrier function. This review highlights recent advances in our understanding of how these genital conditions lead to an increased risk of HIV infection in women.
Publication types
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Research Support, N.I.H., Extramural
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Review
MeSH terms
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Acquired Immunodeficiency Syndrome / immunology*
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Acquired Immunodeficiency Syndrome / transmission*
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Animals
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Disease Susceptibility
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Female
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HIV-1 / pathogenicity
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Humans
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Immunity, Innate
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Lactobacillus / pathogenicity*
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Macaca
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Risk Factors
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Simian Acquired Immunodeficiency Syndrome / immunology*
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Simian Acquired Immunodeficiency Syndrome / transmission
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Trichomonas Vaginitis / immunology*
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Trichomonas Vaginitis / microbiology
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Trichomonas Vaginitis / veterinary
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Trichomonas vaginalis / pathogenicity*
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Vaginosis, Bacterial / immunology*
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Vaginosis, Bacterial / microbiology
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Vaginosis, Bacterial / veterinary