Giving the right tug for migration: cadherins in tissue movements

Sarah F Becker; Rahul Langhe; Chaolie Huang; Doris Wedlich; Jubin Kashef

doi:10.1016/j.abb.2012.02.013

Giving the right tug for migration: cadherins in tissue movements

Arch Biochem Biophys. 2012 Aug 1;524(1):30-42. doi: 10.1016/j.abb.2012.02.013. Epub 2012 Mar 3.

Authors

Sarah F Becker¹, Rahul Langhe, Chaolie Huang, Doris Wedlich, Jubin Kashef

Affiliation

¹ KIT Campus South, Zoological Institute, Department of Cell and Developmental Biology, Germany.

PMID: 22387375
DOI: 10.1016/j.abb.2012.02.013

Abstract

Dynamically regulated cell-cell adhesion is crucial for morphogenesis during embryonic development and tumor progression. The cadherins as calcium-dependent cell-cell adhesion proteins represent key molecules in these tissue movements. How cadherins serve in maintaining tissue cohesion during migration, facilitate cell-cell communication and promote signaling will be summarized in this review.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Cadherins / chemistry
Cadherins / metabolism*
Cell Communication
Cell Movement*
Embryonic Development
Gastrulation
Humans

Substances

Cadherins