Analysis of transmitted resistance to raltegravir and selective pressure among HIV-1-infected patients on a failing HAART in Sao Paulo, Brazil

J Clin Microbiol. 2012 Jun;50(6):2122-5. doi: 10.1128/JCM.00539-12. Epub 2012 Mar 7.

Abstract

We studied the presence of primary resistance to raltegravir (RAL), natural polymorphisms, and selection pressure on HIV-1 integrase. We found a high frequency of integrase polymorphisms related to the resistance to RAL and sequence stability. Further studies are needed to determine the importance of these polymorphisms to RAL resistance.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Anti-HIV Agents / pharmacology*
  • Antiretroviral Therapy, Highly Active / methods*
  • Brazil / epidemiology
  • Drug Resistance, Viral*
  • Female
  • HIV Infections / epidemiology
  • HIV Infections / transmission*
  • HIV Infections / virology
  • HIV Integrase / genetics
  • HIV-1 / drug effects*
  • HIV-1 / isolation & purification
  • Humans
  • Male
  • Molecular Sequence Data
  • Phylogeny
  • Polymorphism, Genetic
  • Pyrrolidinones / pharmacology*
  • Raltegravir Potassium
  • Selection, Genetic*
  • Sequence Homology, Amino Acid
  • Treatment Failure

Substances

  • Anti-HIV Agents
  • Pyrrolidinones
  • Raltegravir Potassium
  • HIV Integrase