Unusual insertion and deletion at codon 67 and 69 of HIV type 1 subtype C reverse transcriptase among first-line highly active antiretroviral treatment-failing South Indian patients: association with other resistance mutations

AIDS Res Hum Retroviruses. 2012 Dec;28(12):1763-5. doi: 10.1089/AID.2011.0331. Epub 2012 May 21.

Abstract

We report a high frequency of drug resistance mutations among patients with unusual insertions or deletions at the β(3)-β(4) hairpin-loop-coding region of HIV-1 subtype C reverse transcriptase, during failure of first-line antiretroviral therapy containing only reverse transcriptase inhibitors in Chennai, India.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Anti-HIV Agents / administration & dosage*
  • Antiretroviral Therapy, Highly Active / methods*
  • Drug Resistance, Viral
  • Female
  • HIV Infections / drug therapy
  • HIV Infections / virology*
  • HIV Reverse Transcriptase / genetics*
  • HIV-1 / genetics*
  • HIV-1 / isolation & purification
  • Humans
  • India
  • Male
  • Middle Aged
  • Mutagenesis, Insertional*
  • Mutant Proteins / genetics
  • Sequence Deletion*
  • Treatment Failure

Substances

  • Anti-HIV Agents
  • Mutant Proteins
  • reverse transcriptase, Human immunodeficiency virus 1
  • HIV Reverse Transcriptase