Expression of soluble HLA-G in multiple myeloma patients and patients with renal failure

Leuk Res. 2012 Jul;36(7):881-3. doi: 10.1016/j.leukres.2012.02.015. Epub 2012 Mar 13.

Abstract

Human lymphocyte antigen-G (HLA-G) is an immunosuppressive molecule that induces functional silencing of immune component cells and can be responsible for immunosuppression in patients with multiple myeloma (MM). Immune dysfunction is an important feature of MM and leads to infections as well as may promote disease progression. Ninety-five patients were included in this study. In MM, the sHLA-G levels were increased when compared to healthy volunteers and the levels of sHLA-G correlated with concentration of creatinine. Interestingly, we detected high levels of sHLA-G in patients with renal insufficiency without any malignant disease but levels were lower than in MM.

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Case-Control Studies
  • Cohort Studies
  • Creatinine / analysis
  • Creatinine / blood
  • Female
  • HLA-G Antigens / blood*
  • HLA-G Antigens / metabolism
  • Humans
  • Male
  • Middle Aged
  • Multiple Myeloma / blood*
  • Multiple Myeloma / immunology
  • Multiple Myeloma / metabolism
  • Osmolar Concentration
  • Renal Insufficiency / blood*
  • Renal Insufficiency / immunology
  • Renal Insufficiency / metabolism
  • Solubility
  • Young Adult

Substances

  • HLA-G Antigens
  • Creatinine