Molecular analysis of FMR1 reactivation in fragile-X induced pluripotent stem cells and their neuronal derivatives

J Mol Cell Biol. 2012 Jun;4(3):180-3. doi: 10.1093/jmcb/mjs007. Epub 2012 Mar 19.
No abstract available

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antimetabolites, Antineoplastic / pharmacology
  • Azacitidine / pharmacology
  • Cell Differentiation
  • Cells, Cultured
  • Chromatin Assembly and Disassembly
  • Epigenesis, Genetic
  • Fragile X Mental Retardation Protein / genetics*
  • Fragile X Mental Retardation Protein / metabolism
  • Fragile X Syndrome / genetics*
  • Histone Deacetylase Inhibitors / pharmacology
  • Humans
  • Hydroxamic Acids / pharmacology
  • Induced Pluripotent Stem Cells / cytology
  • Induced Pluripotent Stem Cells / drug effects*
  • Induced Pluripotent Stem Cells / metabolism
  • Mice
  • Neurons / drug effects*
  • Neurons / metabolism

Substances

  • Antimetabolites, Antineoplastic
  • FMR1 protein, human
  • Histone Deacetylase Inhibitors
  • Hydroxamic Acids
  • Fragile X Mental Retardation Protein
  • trichostatin A
  • Azacitidine