Drimane-type sesquiterpenes with a dioxabicyclooctane skeleton from the fruiting bodies of Nigrofomes melanoporus and their cytotoxicity

Planta Med. 2012 May;78(7):737-9. doi: 10.1055/s-0031-1298367. Epub 2012 Mar 21.

Abstract

Two new drimane-type compounds, nigrofomins A ( 1) and B ( 2), possessing a rare dioxabicyclooctane moiety, were purified from the fruiting bodies of Nigrofomes melanoporus. Their structures were determined using 1D-, 2D-NMR and HR-ESI-MS spectroscopic analyses. In addition, 1 was established by X-ray crystallographic studies. Both nigrofomins A ( 1) and B ( 2) exhibited cytotoxicity on acute T-cell leukemia (Jurkat), human nasopharyngeal carcinoma (NPC-TW01), and lung cancer (NCI-H661) cells with IC (50) values in the range of 99.44-246.32 µM. Furthermore, the effects of 1 and 2 on cell-cycle progression of Jurkat cells displayed a concentration-dependent accumulation in the G (0)/G (1) phase.

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents, Phytogenic / chemistry
  • Antineoplastic Agents, Phytogenic / isolation & purification*
  • Antineoplastic Agents, Phytogenic / pharmacology*
  • Cell Cycle / drug effects
  • Cell Line, Tumor
  • Coriolaceae / chemistry
  • Dose-Response Relationship, Drug
  • Drug Screening Assays, Antitumor
  • Fruiting Bodies, Fungal / chemistry
  • Humans
  • Inhibitory Concentration 50
  • Jurkat Cells / drug effects
  • Lung Neoplasms / drug therapy
  • Molecular Conformation
  • Nasopharyngeal Neoplasms / drug therapy
  • Precursor T-Cell Lymphoblastic Leukemia-Lymphoma / drug therapy*
  • Sesquiterpenes / chemistry
  • Sesquiterpenes / isolation & purification
  • Sesquiterpenes / pharmacology*
  • Vietnam

Substances

  • Antineoplastic Agents, Phytogenic
  • Sesquiterpenes
  • nigrofomin A
  • nigrofomin B