Aromatic DNA adducts in white blood cells of coke workers

Int Arch Occup Environ Health. 1990;62(6):467-70. doi: 10.1007/BF00379065.

Abstract

White blood cell DNA adducts were measured in coke workers, local controls and countryside controls using the 32P-postlabelling technique. The method detected aromatic adducts including those formed by polycyclic aromatic hydrocarbons (PAHs). Coke workers are heavily exposed to PAHs particularly when working at the batteries. A difference in adduct levels was noted between the coke workers at the battery as compared to other jobs. The adduct levels in the non-battery were higher than those in the countryside controls.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Air Pollutants, Occupational / analysis
  • Autoradiography
  • Benzo(a)pyrene / analysis*
  • Carcinogens, Environmental / blood*
  • Chromatography, Thin Layer
  • Coke / adverse effects*
  • DNA / blood*
  • DNA Adducts*
  • Environmental Monitoring
  • Humans
  • Leukocytes / chemistry*
  • Metallurgy*

Substances

  • Air Pollutants, Occupational
  • Carcinogens, Environmental
  • Coke
  • DNA Adducts
  • benzo(a)pyrene-DNA adduct
  • Benzo(a)pyrene
  • DNA