Sensitivity of QuantiFERON-TB GOLD In-Tube for diagnosis of recent versus remote M. tuberculosis infection

Jemianne Bautista; Niaz Banaei

doi:10.1016/j.diagmicrobio.2012.03.018

Sensitivity of QuantiFERON-TB GOLD In-Tube for diagnosis of recent versus remote M. tuberculosis infection

Diagn Microbiol Infect Dis. 2012 Jul;73(3):257-9. doi: 10.1016/j.diagmicrobio.2012.03.018. Epub 2012 Apr 20.

Authors

Jemianne Bautista¹, Niaz Banaei

Affiliation

¹ Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA.

PMID: 22521052
DOI: 10.1016/j.diagmicrobio.2012.03.018

Abstract

The sensitivity of QuantiFERON-TB GOLD In-Tube was measured in 104 subjects with recent (≤2 years) and remote Mycobacterium tuberculosis infection using tuberculin skin test conversion as the reference standard. The sensitivity was not significantly different between the 2 groups (33% versus 20%, P = 0.3). This finding suggests interferon-γ release assays may not be more sensitive for diagnosis of recent than remote infection. Longitudinal studies are needed to validate this finding.

Publication types

Evaluation Study

MeSH terms

Adult
Female
Humans
Interferon-gamma Release Tests / methods*
Male
Middle Aged
Mycobacterium tuberculosis / immunology*
Sensitivity and Specificity
Tuberculin Test
Tuberculosis / diagnosis*
Tuberculosis / immunology