Bortezomib-induced severe autonomic neuropathy

A Stratogianni; M Tosch; H Schlemmer; J Weis; I Katona; S Isenmann; C A Haensch

doi:10.1007/s10286-012-0164-8

Bortezomib-induced severe autonomic neuropathy

Clin Auton Res. 2012 Aug;22(4):199-202. doi: 10.1007/s10286-012-0164-8. Epub 2012 Apr 25.

Authors

A Stratogianni¹, M Tosch, H Schlemmer, J Weis, I Katona, S Isenmann, C A Haensch

Affiliation

¹ Department of Neurology and Clinical Neurophysiology, Autonomic Laboratory, HELIOS-Klinikum Wuppertal, University of Witten/Herdecke, Heusnerstr. 40, 42283 Wuppertal, Germany.

PMID: 22532274
DOI: 10.1007/s10286-012-0164-8

Abstract

Peripheral neuropathy is a known side effect of bortezomib therapy. Acute autonomic neuropathy may also follow treatment with this cytotoxic agent used for treatment of multiple myeloma. Here, we report clinical characteristics and patterns of autonomic involvement in a 75-year-old patient who presented with recurring syncopes.

Publication types

Case Reports

MeSH terms

Aged
Antineoplastic Agents / adverse effects*
Autonomic Nervous System Diseases / chemically induced*
Autonomic Nervous System Diseases / diagnosis
Autonomic Nervous System Diseases / physiopathology
Boronic Acids / adverse effects*
Bortezomib
Humans
Male
Multiple Myeloma / drug therapy*
Peripheral Nervous System Diseases / chemically induced*
Peripheral Nervous System Diseases / diagnosis
Peripheral Nervous System Diseases / physiopathology
Pyrazines / adverse effects*
Severity of Illness Index*

Substances

Antineoplastic Agents
Boronic Acids
Pyrazines
Bortezomib