Immunodeficiency diseases with rheumatic manifestations

Pediatr Clin North Am. 2012 Apr;59(2):493-507. doi: 10.1016/j.pcl.2012.03.010.

Abstract

Most clinicians associate primary immunodeficiency disorders (PIDDs) with susceptibility to frequent or severe infections. It is less commonly recognized, however, that PIDDs are frequently associated with autoimmune or rheumatologic manifestations. This review provides a synopsis of the rheumatic manifestations associated with immunodeficiencies in each of the major compartments of the immune system.

Publication types

  • Review

MeSH terms

  • Adaptive Immunity
  • Autoimmune Diseases / diagnosis
  • Autoimmune Diseases / immunology*
  • Humans
  • Immunity, Innate
  • Immunologic Deficiency Syndromes / complications*
  • Immunologic Deficiency Syndromes / diagnosis
  • Immunologic Deficiency Syndromes / epidemiology
  • Lupus Erythematosus, Discoid / diagnosis
  • Lupus Erythematosus, Discoid / immunology
  • Lupus Erythematosus, Systemic / diagnosis
  • Lupus Erythematosus, Systemic / immunology
  • Rheumatic Diseases / diagnosis
  • Rheumatic Diseases / immunology*
  • United States / epidemiology