Effect of thymic hormones on induction of experimental allergic encephalomyelitis in old mice

Tohoku J Exp Med. 1990 Aug;161(4):303-9. doi: 10.1620/tjem.161.303.

Abstract

This study was aimed at restoring decreased T-cell functions and reduced susceptibility to proteolipid apoprotein (PLP) induced-experimental allergic encephalomyelitis (EAE) in old mice with thymic hormones. Thymosin fraction 5 (TF-5) and serum thymic factor (FTS) had no significant in vitro and in vivo effect on proliferative responses to PLP and concanavalin A (Con A), and on EAE induction in young and old mice. These results suggest that decreased T-cell functions cannot be restored by these thymic hormones tested.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aging / immunology
  • Animals
  • Apoproteins / immunology
  • Encephalomyelitis, Autoimmune, Experimental / etiology*
  • Encephalomyelitis, Autoimmune, Experimental / immunology
  • Encephalomyelitis, Autoimmune, Experimental / prevention & control
  • Female
  • In Vitro Techniques
  • Lymphocyte Activation / drug effects
  • Mice
  • Mice, Inbred BALB C
  • Myelin Proteins / immunology
  • Myelin Proteolipid Protein*
  • T-Lymphocytes / drug effects
  • T-Lymphocytes / immunology
  • Thymic Factor, Circulating / pharmacology
  • Thymosin / analogs & derivatives
  • Thymosin / pharmacology
  • Thymus Hormones / pharmacology*

Substances

  • Apoproteins
  • Myelin Proteins
  • Myelin Proteolipid Protein
  • Thymus Hormones
  • thymosin fraction 5
  • Thymosin
  • Thymic Factor, Circulating